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KMID : 0525720170220010016
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Journal of Chitin and Chitosan
2017 Volume.22 No. 1 p.16 ~ p.22
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Effect of Ethylene Vinyl Alcohol and Cellulose Acetate Butyrate on Drug Release and Mechanical Property of Drug-eluting Stent
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Jang Bu-Nam
Kang Sung-Nam
Kum Chang-Hun
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Abstract
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Although drug-eluting stents have reduced the problem of restenosis, such stents exhibit side effects such as inhibition of re-endothelialization and inflammatory reactions due to persistent drug reactions and sensitivity of polymers. To solve this problem, suppressing the continuous drug reaction by controlling drug release behavior induce rapid vascular re-endothelization. In this study, we attempted to control drug release from a paclitaxel- and cilostazol-containing stent using ethylene vinyl alcohol (EVOH). We then used a scanning electron microscope and atomic force microscope to observe changes on the surface of the drug-releasing stent following the inclusion of EVOH in comparison with stent without EVOH. There were almost no differences on the surface of the drug-eluting stent due to EVOH. The drug release was initially higher in the EVOH-containing stent compared to the stent without EVOH, and the degradation behavior of the polymer not affected by addition of EVOH. Cytotoxicity of the stent containing EVOH was evaluated. EVOH did not exhibit any cytotoxicity due to the degree of controlled release of the drug. Additionally, mechanical property of stent was confirmed by using EVOH and cellulose acetate butyrate (CAB). Radial force increased in stent with EVOH compared to without EVOH although flexibility was not changed. These results suggest that the application of EVOH to drug-eluting stents does not affect the degradation behavior of the stent surface and polymer, but it could be expected to suppress the sustained and excessive response of the drug by rapid release of the drug.
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KEYWORD
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Drug-eluting stent, Drug release, Evoh, Cab, Paclitaxel
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